Therapeutic effects of oyster mushroom in chromium induced toxicities in mice

Abstract

Chromium (Cr) content in poultry feed poses a potential risk of toxicity both for human and animal health. The research work was conducted to evaluate the adverse effect of Cr in adult male mice and ascertained the role of oyster mushroom in alleviating Cr toxic effects. A total of 40 mice (Swiss Albino), four weeks of age were used in the experiment. Mice treated with Cr showed a significant (p<0.01) decrease in value of total erythrocyte count (TEC), hemoglobin (Hb), packed cell volume (PCV) and total leukocyte count (TLC), whereas value of erythrocyte sedimentation rate (ESR) and mean corpuscular volume (MCV) were significantly increased (p<0.01) in relation to control. The values of TEC, Hb and PCV in mushroom treated groups were insignificantly differ but TLC values was slightly increased than healthy control. Administration of mushroom with Cr, values of TEC, Hb, PCV and TLC values were significantly increased(p<0.01) and ESR values was significantly group. Total proteins decreased significantly, while alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), urea, and creatinine increased significantly (p< 0.01) in Cr treated mice indicates the impairment of liver and kidney functions. Biochemical marker of liver profiles showed decreased in co-administration of mushroom along with Cr treated group. Moreover, creatinine and urea in the kidney also decreased while total protein increased significantly (p<0.05) in mushroom treated mice. Thus, Cr cause damage not only to hematological parameters but also causes adverse effects on liver and kidney in mice. Oral administration of oyster mushroom have therapeutic changes observed in all parameters, especially liver and kidney function test. Therefore, our finding concluded that oyster mushroom possess ameliorative effect against Cr induced toxicity in mice and may be useful in amelioration of metal toxicity in human and animals. decreased (p<0.01) compared to Cr alone treated