Abstract:
Oral anti-diabetic agents have a number of serious
adverse effects, thus, managing diabetes without any
side effects is still a major challenge. Therefore, the
search for many effective and safer hypoglycemic
agents from herbal plants are being considered as an
important area of investigation. The aim of this
research was to investigate the effect of Moringa
oleifera (MO) on blood glucose levels, serum total
cholesterol, hematological parameters, body weight
and histopathological assessment of different organs in
alloxan-induced diabetic rats. The rats were divided
into 3 equal groups, each containing 15 individuals
as follows: normal control (C) group, diabetic
control (DC) group and diabetic treatment (DT) group.
Diabetes was induced in diabetic control (DC) and
diabetic treatment (DT) group with alloxan @
200mg/kg body weight intra-peritoneal. Diabetes was
induced in diabetic control (DC) and diabetic treatment
(DT) group with alloxan @ 200mg/kg body weight
Key Words: Moringa, antidiabetic, rat, kidney, pancreas intraperitonially. Then DT group was treated with
aqueous extract of MO @150 mg/kg body weight.
After 42 days of treatment, MO extract reduced the
amount of blood glucose significantly (p<0.001) in the
group DT compared to DC from 31.41 ± 0.44 to 16.61
± 0.33 mmol/L. Total cholesterol (TC) was lowered
significantly (p<0.01) in DT compared to DC from
154.122 ± 3.41 to 108.489 ± 0.31mg/dL. In
hematological study, DT group showed significant
(p<0.001) elevation of erythrocyte count and demotion
(p<0.01) of leukocyte count after 42 days of treatment
in contrast with DC group. The body weight was also
increased significantly (p<0.001) in DT group.
Moreover, in histopathological examination, the MO
therapy in diabetic rats showed mild regeneration of
the pancreatic acini and islets of Langerhans compared
to DC which indicate the organo-protective effect of
MO. Based on present research it can be concluded that
MO can be used as anti-diabetogenic agent in food.
