Abstract:
The study was undertaken to investigate the effects of Telakucha (Coccinia indica) on
blood glucose, serum total cholesterol, hematological parameters and body weight on
alloxan induced diabetic rats. Forty five rats were divided into 3 equal groups: Control
(C), Diabetic Control (DC) and Diabetic Treatment (DT). DT group was treated with
10% aqueous extract of Telakucha 500 mg/kg body weight. Telakucha extract
reduced the amount of blood glucose significantly (P<0.001) in the group DT
compared to DC from 32.03 ± 0.25
to 11.17 ± 0.08 mmol/L. Total cholesterol (TC)
was decreased significantly (P<0.001) in group DT compared to group DC from
121.85
±0.27 to 112.42±0.14 mg/dL. In hematological study, DT group showed
significant (P<0.001) increase of erythrocytes count & Hb (g%) content and decrease
(P<0.001) of total leukocyte count after 42 days of treatment in contrast with DC
group. The body weight was also increased significantly (P<0.001) in DT group.
Based on present research it can be concluded that Telakucha can be used in the
treatment of diabetes as an alternative to commercial medicine.
Description:
A Thesis
Submitted to the Department of Anatomy, Histology & Physiology,
Sher-e-Bangla Agricultural University, Dhaka-1207, in partial fulfillment
of the requirements for the degree of
MASTER OF SCIENCE (MS) IN ANATOMY
DEPARTMENT OF ANATOMY, HISTOLOGY &
PHYSIOLOGY
