Effects of Edible Oils on Biochemical Parameters of Blood in Mice

Abstract

The study was conducted on “Swiss Albino” mice (Mus musculus) fed with additional supplementation of rice bran oil, soybean oil and palm oil to observe their effects on biochemical parameters (total ser um cholesterol, triglycerides, high densi t y lipoproteins and creatinine). A total of 40 (4-5weeks old) mice were randomly divided into 4 equal groups (n=10) as A, B, C and D. Group A was considered as control, fed only commercial ration and other groups were supplemented with rice bran oil (group B), soybean oil (group C) and palm oil (group D) respectively in addition to commercial ration for 60 days. The serum total cholesterol in oil treated groups differed significantly (p<0.05) from control group (95.43 ± 2.16 mg/dl) and was highest in palm oil group (131.468 ± 2.6 mg/dl) among the oil treated groups. The triglycerides in palm oil (172.32 ± 3.09 mg/dl) treated group varied significantly (p<0.05) from control (150.79 ± 3.95 mg/dl) and other oil treated groups. The serum creatinine in palm oil (1.15 ± 0.96 mg/dl) treated group also varied significantly (p<0.05) from control (0.69 ± 0.04 mg/dl) and other oil treated groups. The high density lipoprotein (HDL) in soybean oil treated group (79.48 ± 5.87) differed significantly (p<0.05) from palm oil (63.72 ± 6.81) and control groups (54.47 ± 4.54) but close to rice bran oil group (73.19 ± 3.96). Further investigation is necessary with large number of animals and addition of more parameters like liver function, kidney function which will give more precise information about the effect of these oils.